The Top NMN and NR Supplements of 2024

Highlights

• The top NMN and NR supplements are as follows:
  • RESTORIN
  • Thorne NiaCel 400
  • ProHealth Longevity’s NMN Pro Complete
  • Quicksilver Scientific NAD+ Platinum
  • Cymbiotika NMN + Trans-Resveratrol
  • Revigorator

The products chosen that include the top NAD+ precursor molecules nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) combine multiple ingredients. Adding multiple molecules with possible age-slowing benefits may confer interactions between these compounds that produce an effect greater than the sum of their separate effects — synergy. In this way, possible synergistic benefits from multiple molecular technologies may serve to slow aging better than NMN or NR on their own. Listed below are six promising NMN or NR-containing complexes with added molecular technologies, which we believe give you the best bang for your buck.

RESTORIN

With NAD+-optimizing molecules, sirtuin-activating compounds (STACs), and senolytics, RESTORIN serves as a quintessential longevity formula. The NAD+-optimizing compounds included in RESTORIN, likely B₃ vitamins like nicotinamide riboside (NR), combined with senolytics and STACs act synergistically to possibly slow aging.

RESTORIN’s compounds for NAD+ level optimization have been associated with increasing insulin sensitivity, improving physical performance, and enhancing skin health. The included senolytics selectively eliminate dysfunctional cells that contribute to inflammation as we get older called senescent cells. The RESTORIN formula also includes STACs that propel the function of proteins called sirtuins, which modulate cell metabolism and DNA repair. The formula’s inclusion of all three of these technologies may increase the likelihood of staving off aging’s effects.

Thorne NiaCel 400

Thorne NiaCel 400 includes the NAD+-optimizing compound NR. This formula also contains trimethylglycine (TMG), a compound believed to enhance physical performance. While more clinical trials are needed for confirmation, Thorne NiaCel 400’s combination of NR and TMG may help dampen the effects of aging all the while improving physical function.

ProHealth Longevity’s NMN Pro Complete

ProHealth Longevity’s NMN Pro Complete contains the effective NAD+-optimizing molecule nicotinamide mononucleotide (NMN). On top of that, it includes resveratrol, found in grapes, red wine, and peanuts. Studies suggest that resveratrol works against diabetes, obesity, and aging itself. Finally, the NMN Pro Complete complex contains TMG, which may promote physical function. The addition of resveratrol and TMG to NMN makes ProHealth Longevity’s NMN Pro Complete a prominent formula that may have age-slowing effects.

Quicksilver Scientific NAD+ Platinum

Quicksilver Scientific NAD+ Platinum contains six compounds that may serve to prevent the effects of aging. As for NAD+-optimizers, it contains NMN; however, only 50 milligrams are included per serving.

At the same time, Quicksilver Scientific NAD+ Platinum contains other molecules with possible age-slowing effects. Such compounds include TMG, which may enhance physical performance. Another is riboflavin, which may confer anti-inflammatory effects.

Some people are also deficient in vitamin B₁₂, which can lead to fatigue. The Quicksilver Scientific NAD+ Platinum formula includes vitamin B₁₂ to increase its levels in circulation.

What’s more, this formula contains quercetin, a plant-derived flavonoid that has senolytic properties. The quercetin included in this complex is believed to eliminate senescent cells.

Moreover, Quicksilver Scientific NAD+ Platinum has TMG. TMG may enhance physical performance capacity.

Finally, Quicksilver Scientific NAD+ Platinum includes resveratrol. Resveratrol may help against diabetes, obesity, and aging, rounding off this supplement’s possible age-slowing benefits.

Cymbiotika NMN + Trans-Resveratrol

Cymbiotika NMN + Trans-Resveratrol contains five compounds that may work against aging. An important one is NMN. Another is apigenin, a plant-derived flavonoid believed to boost cardiovascular health and brain function. Moreover, this formula contains green tea extract that may quell inflammation. On top of that, Cymbiotika NMN + Trans-Resveratrol contains, as expected, resveratrol that may confer anti-diabetes, anti-obesity, and anti-aging benefits. Last, this formulation contains green coffee bean extract, which may work against obesity, although scientific evidence for these effects is still lacking.

Revigorator

Revigorator Gen 4 Platinum makes the list as another prominent compound that may effectively work against aging. This formula contains NAD+ precursors, along with a molecular analog to resveratrol called pterostilbene. Pterostilbene has a much greater bioavailability — the proportion of a compound that enters circulation when introduced to the body — than resveratrol. Thus, pterostilbene likely shares the same benefits as resveratrol but with possible amplified effects.

Revigorator Gen 4 Platinum also contains quercetin and fisetin — two plant-derived flavonoids known as senolytics.

The Revigorator Gen 4 Platinum complex also contains a flavonoid called icariin from the horny goat weed plant. Icariin is believed to confer anti-inflammatory benefits.

What’s more, Revigorator Gen 4 Platinum contains a B vitamin complex. This complex of B vitamins may help prevent cognitive decline, conferring potential benefits dependent on factors like environment and diet. Taking the B vitamin complex in Revigorator Gen 4 Platinum may enhance brain health in aged adults grappling with reduced cognitive function.

With NAD+ precursors, pterostilbene, senolytics, icariin, and a vitamin B vitamin complex, Revigorator Gen 4 Platinum is yet another quintessential longevity formula. The molecules included in this formula for possible age-slowing effects put its quality in contention with other top NAD+-boosting products.

Taking any of these supplements may confer synergistic benefits from adding compounds like TMG, senolytics, or STACs to the NAD+-optimizing molecules NMN or NR. Using any of the formulas included in this list may help to enhance metabolism and reduce inflammation, thereby possibly slowing aging processes.