The company Metro International Biotech, which has David Sinclair on its scientific advisory board, has unveiled that its NAD+-boosting drug MIB-725 has begun undergoing human trials.

NMN (nicotinamide mononucleotide) enhances the effect of longevity-associated sirtuin enzymes against metabolic syndrome in rats.

A new study reveals that tiny vesicles secreted by young stem cells can reverse multiple signs of cardiac aging in mice.

Fucoidan activates the longevity-associated enzyme sirtuin 6 (SIRT6), which prolongs the lifespan of mice while improving their health.

People in Blue Zones—regions where higher percentages of people live past 100—eat ample amounts of plant-derived compounds called polyphenols, which modulate hallmarks of aging.

A formulation of 10 human-derived probiotics — beneficial gut bacteria — counter Alzheimer’s progression and improve gut health in mice.

A mix of filtered milk, egg yolk extract, nicotinamide mononucleotide (NMN), quercetin, ɑ-ketoglutarate, white button mushroom, and celery seed extract enhances immune cell killing action against cancer cells.

Cellular reprogramming, a technique currently being investigated as an age-reversal therapy, helps a paralyzed man walk again by regenerating his spinal cord neurons.

María Branyas Morera died last year at the phenomenal age of 117, and a new study of her medical features reveals some possible longevity-promoting characteristics like beneficial gut bacteria.

Both NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are converted to NA (nicotinic acid) by the gut before being made into NAD+ (nicotinamide adenine dinucleotide).

The most measured man in the world, Bryan Johnson, reveals his results from 90 days of hyperbaric oxygen therapy.

Scientists find that a GLP-1 receptor agonist similar to the weight loss drug Ozempic activates sirtuins to modulate bone health in rats.

According to Retro Biosciences CEO Joe Betts-LaCroix, a whopping 85% of healthcare pertains to treating aging-related ailments, and he unveils three of his company’s strategies to mitigate them.

In older adults, liposomal NMN — NMN carried in membranes — increases NAD+ (nicotinamide adenine dinucleotide) levels more than non-liposomal NMN.

Rising interest in longevity has spawned disease-prevention clinics like Peter Attia’s Biograph, Matt Kaeberlein’s Optispan, and J. Craig Venter’s Human Longevity.