Omega-3 fatty acids reduce stress hormone and inflammatory responses

The key nutrient in fish oil called omega-3 keeps aging markers like diminished telomerase, elevated inflammation, and increased levels of the stress hormone cortisol at bay.

An NAD+ consuming enzyme is a new target to protect against epilepsy-induced brain damage

The NAD+ consuming enzyme CD38 is a new target to prevent brain damage induced by seizures in a condition called epilepsy.

Neurological

Bigmouth buffalo can help us uncover what underlies the pace of aging

An extremely long-lived freshwater fish native to North America called the bigmouth buffalo shows improved rather than diminished immune function with age.

Treating immature mouse fat cells with nicotinamide mononucleotide (NMN) improves metabolism and inflammation-related gene activity.

Treating mouse immature fat cells with nicotinamide mononucleotide (NMN) increases activity of metabolic health genes and decreases gene activity related to inflammation and scarring.

This yellow plant pigment holds promise in delaying aging and treating age-related diseases

Fisetin is a yellow micronutrient that comes from plants and may have anti-aging properties along with delaying age-related diseases.

A human clinical trial shows that nicotinamide mononucleotide (NMN) improves metabolism in aged women with prediabetes.

In a first, researchers show that treating aged, prediabetic women with NMN improves their muscle insulin sensitivity and metabolism and increases blood cell NAD+ levels.

Metabolism

In potential breakthrough research, experts are measuring cell and tissue decline to better understand how we age and to make better aging therapeutics.

Scientists are using cell and tissue decline measurements to look at biological aging for better aging research and to develop better antiaging therapeutics.

Basic Research

In recent years, cell senescence has fallen into the biomedical limelight, with these ‘zombie cells’ serving up a rich source of opportunities for innovative therapeutic development in aging and age-related diseases.

An in-depth look into cell senescence and how these zombie cells contribute to developments in age-related diseases and aging.

Senescent Cells Explained - NMN

Researchers fight off childhood neurodegenerative disease characteristics rooted in NAD+ deficiency, mitochondrial damage, and senescence

Boosting NAD+ levels helps stave off childhood neurodegenerative disease rooted in NAD+ deficiency, senescence, and mitochondrial damage.

Longevity

Nanocrystals with nicotinamide riboside and resveratrol enhance NAD+ levels in mouse organs

NAD+ boosting nanocrystals containing nicotinamide riboside and resveratrol help with heart damage and dysfunction following injury in mice.

Cardiovascular

Boosting NAD+ after injury suppresses tissue damage and scarring.

NMN boosts NAD+ levels to reduce DNA damage and subsequent kidney tissue scarring in mice with potential translatability to people.

Others

This indicator can facilitate research and clinical trials of drugs that target age-related diseases

An indicator to evaluate drugs that target aged cells can help with research for anti-aging and age-related disease purposes.

Supplementing with the antioxidant precursor combination provides a simple and effective means to enhance human health.

Supplementing with the antioxidant precursors in GlyNAC reduces oxidative stress and improves physical and cognitive function in aged adults.

Increasing NAD+ levels could represent a promising and safe therapeutic strategy for chemotherapy medicine-related neurotoxicity

Cisplatin chemotherapy-induced cognitive impairment from neurotoxicity is ameliorated with NAD+-boosting nicotinamide mononucleotide (NMN).

Cancer

A drug cocktail reduces brain inflammation and improves cognitive function in aged mice

A drug cocktail reduces brain inflammation by eliminating aged, non-proliferating cells to improve cognitive function in aged mice.

Stimulating a longevity-linked protein with nicotinamide mononucleotide (NMN) reduces tissue scarring progression and subsequent kidney disease.

Stimulating the SIRT1 protein with nicotinamide mononucleotide (NMN) attenuates the progression of kidney scarring by diminishing the activity of the HIF-2a protein.

Studies

NEWS

NMN Stimulates Metabolic Gene Activity in Fat Cells

Metabolic Benefits of NMN Shown for First Time in Humans