Nicotinamide mononucleotide (NMN) clears aged, non-proliferating lung cells from cigarette smoke.

Nicotinamide mononucleotide boosts NAD+ levels to mitigate senescent cell buildup and cigarette smoke-induced pulmonary fibrosis.

This plant pigment may alleviate age-related dysfunction and disease in humans

A plant metabolic byproduct called fisetin targets aged, non-proliferating cells in human tissues and extends mouse lifespan.

Longevity

Nicotinamide (NAM) ameliorates neuron connection integrity in mice with reduced brain blood flow

Treatment with NAD+ precursor nicotinamide improves cognition and brain white matter integrity in mice with chronic cerebral hypoperfusion.

In an interview, this experienced drug hunter shares his insights on how to best raise NAD+ levels.

Airway delivery of a longevity-linked gene resolves age-associated persistent lung fibrosis in mice

(mr.suphachai praserdumrongchai | iStock)

Delivering longevity-linked gene SIRT3 mitigates age-related lung fibrosis in mice

Immune cell signals that activate muscle stem cells like NAMPT have therapeutic potential for muscle injury and disease

Supplementation with the protein NAMPT enhances muscle regeneration after injury in fish and mice.

Skin &amp; Muscle

One week of nicotinamide riboside (NR) supplementation did not affect whole-body metabolic adaptation before, during, or after working out

Pre-workout nicotinamide riboside (NR) supplementation has no effect on whole-body metabolic adaptation before, during, or after exercise.

Can Pre-Workout NR Influence Exercise? | NMN

Senolytic drugs Dasatinib and Quercetin ameliorate mouse intervertebral disc decline when given during a therapeutic window

Combined senolytic drugs Dasatinib and Quercetin ameliorate age-related intervertebral disc degeneration by reducing inflammation.

Others

The study suggests that cognitive aging can be restored by reprogramming immune cell glucose metabolism to rejuvenate immune functions

Stanford scientists revamp the metabolism of immune cells to restore cognition in aged mice.

Study shows that NAD+ boosting reduces age-linked amyloid deposition and restores mitochondrial balance in muscle cells across species

A study indicates boosting NAD+ reduces age-related abnormal proteins called amyloid deposits in muscle cells and restores mitochondrial balance across species.

Studies

NEWS

NMN Alleviates Lung Damage in Cigarette-Induced Pulmonary Fibrosis

Dr. Stephen Gardell on NMN Boosting Drugs