Cellular NAD+ Levels Modulate the Immune Response to COVID-19

Researchers propose that increasing NAD+ levels improves immune function in COVID-19 infection.


The Subdivision of NAD+ into Cell Compartments is Critical to Mammalian Life

Researchers review evidence supporting the importance of how nicotinamide adenine dinucleotide (NAD+) is distributed to different cell structures in health, disease, and aging.


NAD+ Binds to and Inhibits a Protein that Promotes Degeneration of Neurons

Investigators propose that a newly revealed nicotinamide adenine dinucleotide (NAD+) binding site of Sarm1 may be a promising drug target.

A Nutrition Guide for Memory Loss Care and Prevention

When equipped with the right dietary guidelines, vitamins, and social support from close relatives, senior adults can help mitigate and prevent loss of memory. This comprehensive guide shares some of the most simple tactics when it comes to battling disorders that target a person's memory.


Enzyme Regulating NAD+ Keeps Mouse Cells Replicating Under Stress

Genetically modified mouse cells with artificial activation of a nicotinamide adenine dinucleotide (NAD+) regulating enzyme are protected from cessation of cell proliferation induced by stress, maintaining healthy aging.


NR Does Not Improve Mitochondrial Function or NAD+ Content in Human Skeletal Muscle After Long-Term Administration

A long-term clinical study from Denmark showed that increased nicotinamide adenine dinucleotide (NAD+) content and improved mitochondrial function induced by nicotinamide riboside (NR) supplementation in mouse skeletal muscle does not translate into humans.


The Promise of Therapeutically Targeting Sirtuins in Lung Fibrosis

Potential therapeutic modulations of Sirtuins through synthetic- and plant-derived compounds can help design new-generation cheap, non-toxic Sirtuin-based drugs against lung fibrosis.