What does NMN do?

WHAT DOES NMN DO

Research CategorySummary / ConclusionLink #
Bone Repair
  • Doubles the presence of new bone-forming cells in mice.
2, 24
Cancer
  • Increases the potency of PD-1-mediated immunotherapy to reduce tumor size two-fold in mice.
  • Enhances cognition measurements two-fold in mice after chemoteherapy.
3
32
Cardiovascular
  • Doubles the heart's contractile capacity in a heart disease mouse model.
  • Enhances cognition measurements two-fold in mice after chemoteherapy.
  • Doubles the flexibility and elasticity of blood vessels to reverse their functional decline in mice.
4, 26
23
25
DNA Repair
  • Doubles the length of liver cell telomeres in mice with liver fibrosis.
  • Doubles DNA-repairing PARP1 protein activation in older mice.
5
18
Eye Protection
  • Reduces eye cell (photoreceptor) death by four times after their detachment from the retina in mouse eyes.
  • Diminishes eye cell death more than three times in a mouse dry eye disease model.
  • Reduces the size of eye wounds by 25% after nerve fiber detachment.
6
17
31
Immunity
  • NMN cocktail therapy promotes recovery from CoVID-19.
7
Longevity
  • Boosting NMN synthesis in cells more than doubles remaining lifespan in mice.
  • Significantly restores cardiovascular, cognitive, and metabolic decline in mice.
8
20
Metabolism
  • Substantially improves insulin sensitivity in older women.
  • More than doubles mitochondrial cell energy production in mice.
  • Significantly improves insulin sensitivity in mouse age-induced diabetes.
  • Doubles the amount of cell energy-generating mitochondria in the livers of obese mice.
9
21
27, 28
29
Neurological
  • Significantly improves cognition and memory in rodents with Alzheimer's disease.
  • Reduces depressive behavior by half in a mouse depression model.
  • Improves cognitive function by 50% following brain hemorrhage in mice.
  • More than doubles the average time spent stroke-free in rats fed diets high in salt.
10, 22
11
12
33
Reproduction
  • Significantly improves female fertility in mice.
  • Protects egg cells from cell death two-fold from environmental toxin exposure in pigs.
13
19
Skin and Muscle
  • Significantly promotes the activation of genes with roles in muscle remodeling in older women.
9
Organ Health
  • Reduces blood test measurements for liver damage by half in a mouse chronic alcohol consumption model.
  • Reduces kidney cell death by 40% and significantly protects against kidney damage from ischemia injury.
  • Significantly inhibits liver scarring gene activity and subsequent liver scarring in mice.
  • Increases the number of intestinal stem cells by 20% in mice.
14
15
16
30
Mechanism
  • An NMN-specific transporter in mammalian guts called SLC12A8 has been identified.
1