NEWS
Cellular NAD+ Levels Modulate the Immune Response to COVID-19
Researchers propose that increasing NAD+ levels improves immune function in COVID-19 infection.
The Subdivision of NAD+ into Cell Compartments is Critical to Mammalian Life
Researchers review evidence supporting the importance of how nicotinamide adenine dinucleotide (NAD+) is distributed to different cell structures in health, disease, and aging.
NAD+ Binds to and Inhibits a Protein that Promotes Degeneration of Neurons
Investigators propose that a newly revealed nicotinamide adenine dinucleotide (NAD+) binding site of Sarm1 may be a promising drug target.
A Nutrition Guide for Memory Loss Care and Prevention
When equipped with the right dietary guidelines, vitamins, and social support from close relatives, senior adults can help mitigate and prevent loss of memory. This comprehensive guide shares some of the most simple tactics when it comes to battling disorders that target a person's memory.
Enzyme Regulating NAD+ Keeps Mouse Cells Replicating Under Stress
Genetically modified mouse cells with artificial activation of a nicotinamide adenine dinucleotide (NAD+) regulating enzyme are protected from cessation of cell proliferation induced by stress, maintaining healthy aging.
NR Does Not Improve Mitochondrial Function or NAD+ Content in Human Skeletal Muscle After Long-Term Administration
A long-term clinical study from Denmark showed that increased nicotinamide adenine dinucleotide (NAD+) content and improved mitochondrial function induced by nicotinamide riboside (NR) supplementation in mouse skeletal muscle does not translate into humans.
The Promise of Therapeutically Targeting Sirtuins in Lung Fibrosis
Potential therapeutic modulations of Sirtuins through synthetic- and plant-derived compounds can help design new-generation cheap, non-toxic Sirtuin-based drugs against lung fibrosis.
NR Can Enhance T Cell Antitumor Immunity by Restoring Mitochondrial Function
T lymphocytes that infiltrate and suppress tumors progressively lose their ability to function, but nicotinamide riboside (NR) supplementation enhances T cell mitochondrial fitness to sustain the antitumor response.
NAD+ Keeps the Mouse Body Clock Young to Counter Aging
Boosting nicotinamide adenine dinucleotide (NAD+) levels restores improves circadian rhythms in old mice through youthful gene activation and metabolic patterns, revealing that NAD+ governs both behavior and metabolic health.
The Molecules SS-31 and NMN Synergistically Improve Aged Heart Function
Scientists treated old mice with the molecules SS-31 and NMN (nicotinamide mononucleotide) separately to improve different heart functions and when delivered together these molecules acted synergistically to recapitulate the function and metabolism of young hearts.