NEWS
Alzheimer’s Drug Failures Beckon the Importance of Prevention
Recent failed clinical trials for the treatment of Alzheimer’s point to stifled innovation, beckoning for prevention strategies for the generations to come.
NMN, Metformin, and Rapamycin Mitigate Age-Related Cognitive Impairment
The anti-aging compounds NMN, metformin, and rapamycin prevent brain damage and alleviate memory deficiencies in a rat model for age-related cognitive impairment.
Study Suggests Withdrawing Blood Reverses Skin Aging
Blood draining increases proteins responsible for skin firmness, decreases inflammation, and reduces senescent (aged) skin cells in mice.
Scientists Reverse Age-Related Infertility by Boosting Mitochondrial Function
Scar tissue accumulation (fibrosis) in ovaries inhibits ovulation — the release of eggs (oocytes) into the uterus — in obese and aged female mice, but removing fibrotic tissue with pharmaceuticals restores oocyte release.
Regular Sleep-Wake Cycle Essential for Prolonged Lifespan via Dietary Restriction
Buck Institute scientists find that enhanced circadian rhythms and dietary restriction quadruple the lifespan of fruit flies, and are associated with reduced inflammation.
Urolithin A Enhances Physical Performance in Overweight Adults
A clinical trial indicates that urolithin A improves muscle strength, exercise endurance, and cellular markers of mitochondrial health in overweight adults.
Study Shows the Combination of Nicotinamide and D-Ribose Improves Insulin Sensitivity
The nicotinamide and D-Ribose combination RiaGev increases NAD+, improves insulin sensitivity, and lowers the stress hormone cortisol in healthy, middle-aged adults.
NAD+ Precursors NMN and NR Suppress Hyper-Allergic Reactions
NMN and NR serve as potent therapeutics against intense allergic reactions mediated by white blood cell secretions of inflammatory factors in mice.
NMN Dramatically Increases Cellular Energy Metabolism Through AMPK Activation
Treating human cells with NMN triples NAD+ levels and increases the activity of AMPK — an enzyme that turns on sugar and fat metabolism in response to low energy.
The Naturally Occurring Senolytic 25HC Restores Age-Related Muscle Loss
The senolytic molecule 25 hydroxycholesterol (25HC) targets aged, non-proliferating (senescent) cells for clearance to rejuvenate aged muscle in mice.
NAD+ Precursors NMN and NR Prevent Nerve Fiber Degradation in Diabetes
Scientists find that boosting NAD+ with NMN and NR supplementation alleviates diabetes-related nerve fiber degeneration and loss in rodents.
Uthever NMN Does Not Boost NAD+ or Improve Physical Endurance in Middle-Aged and Elderly Adults
Adults aged 40 to 65 years took 300 mg/day of Uthever NMN for 60 days and displayed no significant increases in blood NAD+ or improvements in walking distance.
The Senolytic Navitoclax Improves New Neuron Production and Memory
Navitoclax prunes away aged, non-proliferating (senescent) neurons in the brain to revamp the production of new neurons and enhance learning and memory in aged mice.
NMN Boosts the Efficacy of Cancer-Fighting Immune Cells
Nicotinamide mononucleotide (NMN)-treated antitumor CAR-T cells display enhanced effectiveness to combat cancer cells and reduce tumor growth in mice.
Clinical Study Indicates that NMN Efficaciously Increases Blood NAD+ in Humans
A recently-published University of Toyama study from Japan reveals that a daily intake of 250 mg of nicotinamide mononucleotide (NMN) significantly raises blood NAD+.
What is NMN?
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