Recent failed clinical trials for the treatment of Alzheimer’s point to stifled innovation, beckoning for prevention strategies for the generations to come.
The anti-aging compounds NMN, metformin, and rapamycin prevent brain damage and alleviate memory deficiencies in a rat model for age-related cognitive impairment.
Blood draining increases proteins responsible for skin firmness, decreases inflammation, and reduces senescent (aged) skin cells in mice.
Scar tissue accumulation (fibrosis) in ovaries inhibits ovulation — the release of eggs (oocytes) into the uterus — in obese and aged female mice, but removing fibrotic tissue with pharmaceuticals restores oocyte release.
Buck Institute scientists find that enhanced circadian rhythms and dietary restriction quadruple the lifespan of fruit flies, and are associated with reduced inflammation.
A clinical trial indicates that urolithin A improves muscle strength, exercise endurance, and cellular markers of mitochondrial health in overweight adults.
The nicotinamide and D-Ribose combination RiaGev increases NAD+, improves insulin sensitivity, and lowers the stress hormone cortisol in healthy, middle-aged adults.
NMN and NR serve as potent therapeutics against intense allergic reactions mediated by white blood cell secretions of inflammatory factors in mice.
Treating human cells with NMN triples NAD+ levels and increases the activity of AMPK — an enzyme that turns on sugar and fat metabolism in response to low energy.
The senolytic molecule 25 hydroxycholesterol (25HC) targets aged, non-proliferating (senescent) cells for clearance to rejuvenate aged muscle in mice.
Scientists find that boosting NAD+ with NMN and NR supplementation alleviates diabetes-related nerve fiber degeneration and loss in rodents.
Adults aged 40 to 65 years took 300 mg/day of Uthever NMN for 60 days and displayed no significant increases in blood NAD+ or improvements in walking distance.
Navitoclax prunes away aged, non-proliferating (senescent) neurons in the brain to revamp the production of new neurons and enhance learning and memory in aged mice.
Nicotinamide mononucleotide (NMN)-treated antitumor CAR-T cells display enhanced effectiveness to combat cancer cells and reduce tumor growth in mice.
A recently-published University of Toyama study from Japan reveals that a daily intake of 250 mg of nicotinamide mononucleotide (NMN) significantly raises blood NAD+.