This plant pigment may alleviate age-related dysfunction and disease in humans

A plant metabolic byproduct called fisetin targets aged, non-proliferating cells in human tissues and extends mouse lifespan.

Longevity

Airway delivery of a longevity-linked gene resolves age-associated persistent lung fibrosis in mice

(mr.suphachai praserdumrongchai | iStock)

Delivering longevity-linked gene SIRT3 mitigates age-related lung fibrosis in mice

Research shows that reducing specific dietary amino acids may hold potential as a translatable intervention to promote healthy aging

Dietary protein restrictions specifically eliminating branch-chain amino acids enhanced male mouse longevity and improved metabolism in both sexes.

Kat7 gene inactivation rejuvenates prematurely aging human cells and mice and promotes longevity.

CRISPR-induced KAT7 gene inactivation rejuvenates prematurely aging human cells and mice and promotes longevity.

Changes in the body that come from space travel resemble growing older, providing opportunities to perform aging studies on astronauts.

Spending time in outer space can mimic the effects of aging, and scientists have begun using the unique environment of space as a place to study aging.

How Aging is Affected by Space Travel

Others

Limited rapamycin exposure late in life was as effective as continuous exposure in increasing survival in males but not females

Late-life rapamycin administration regimens enhance mouse lifespan in a sex-dependent manner with limited exposure more effective in males than females.

A study from UPenn scientists shows rapamycin prevents age-related alterations of metabolic state in muscle cells, which may extend lifespan.

Rapamycin increases the NAD+/NADH ratio and subsequent metabolic balance by reducing NADH levels in mouse muscle.

Genetically modified mouse cells with artificial activation of a nicotinamide adenine dinucleotide (NAD+) regulating enzyme are protected from cessation of cell proliferation induced by stress, maintaining healthy aging.

Artificially-activated Nampt enzyme promotes cellular protection from stress-induced cessation of cell proliferation.

Enzyme Regulating NAD+ Facilitates Cell Replication 

A new study in Mechanisms of Ageing and Development on March 9, 2020, describes how aging fits the criteria for a disease under the International Classification of Disease.

Scientists repurposed a blood cancer treatment using genetically modified immune cells called CAR T cells to reverse age-associated tissue damage.

A cellular therapy typically used against blood cancer called CAR T therapy improved tissue health by destroying senescent cells in mice.

Studies

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