A study from UPenn scientists shows rapamycin prevents age-related alterations of metabolic state in muscle cells, which may extend lifespan.

Rapamycin increases the NAD+/NADH ratio and subsequent metabolic balance by reducing NADH levels in mouse muscle.

Longevity

Scientists repurposed a blood cancer treatment using genetically modified immune cells called CAR T cells to reverse age-associated tissue damage.

A cellular therapy typically used against blood cancer called CAR T therapy improved tissue health by destroying senescent cells in mice.

Others

Changes in the body that come from space travel resemble growing older, providing opportunities to perform aging studies on astronauts.

Spending time in outer space can mimic the effects of aging, and scientists have begun using the unique environment of space as a place to study aging.

How Aging is Affected by Space Travel

Genetically modified mouse cells with artificial activation of a nicotinamide adenine dinucleotide (NAD+) regulating enzyme are protected from cessation of cell proliferation induced by stress, maintaining healthy aging.

Artificially-activated Nampt enzyme promotes cellular protection from stress-induced cessation of cell proliferation.

Enzyme Regulating NAD+ Facilitates Cell Replication 

Boosting nicotinamide adenine dinucleotide (NAD+) levels restores improves circadian rhythms in old mice through youthful gene activation and metabolic patterns, revealing that NAD+ governs both behavior and metabolic health.

How NAD+ Counters Aging in the Bodies of Mice

Increasing levels of eNAMPT enzymes in molecular bubbles in the blood delays aging and increases health span and lifespan in mice.

Elevating eNAMPT enzyme levels in mice helps delay premature aging and extends life expectancy.

Enzyme in Blood from Mice Helps Delay Aging and Extends Lifespan

NMN mitigates age-related cellular changes in aged mice intestine stem cells that are caused by the decreased cell proliferation from reduced activation of the Lgr5 gene.

NMN Mitigates Change of Stem Cells in Mice's Intestines

Epigenetics

Scientists showed increasing NAD+ levels promotes longevity and prevents age-related metabolic decline with improved cellular stress signaling in roundworms.

How Proteins and Cellular Pathways Promote Longevity

An international team of scientists from Europe, the US and Australia revealed that boosting NAD+ mitigates DNA damage and improves survival in animals with neurological defects in a 2016 study.

A global science team revealed that boosting NAD+ improves wildlife lifespan with biological defects by mitigating DNA damage.

NAD+ Increases Healthspan and Lifespan in Animals | NMN

DNA Repair

Boosting NAD+ level with natural compound, NMN, for 12 months reduces signs of aging in healthy mice

Studies

NEWS

NMN Suppresses Age-Induced Changes in Intestinal Stem Cells of Mice

Nicotinamide Mononucleotide Supplementation Extends the Healthspan in Mice