Researchers fight off childhood neurodegenerative disease characteristics rooted in NAD+ deficiency, mitochondrial damage, and senescence

Boosting NAD+ levels helps stave off childhood neurodegenerative disease rooted in NAD+ deficiency, senescence, and mitochondrial damage.

Longevity

Fasting every other day improves aged male mouse health and stimulates kidney production of an anti-aging compound.

Fasting every other day improves measures of frailty in aged, male but not female mice, possibly by increasing kidney hydrogen sulfide production.

Gut bacterial composition uniqueness correlates with and can predict patient survival late in life

Gut bacterial composition becomes more unique with age in healthy, longer-living older people who also lose core gut bacterial species abundance.

Airway delivery of a longevity-linked gene resolves age-associated persistent lung fibrosis in mice

(mr.suphachai praserdumrongchai | iStock)

Delivering longevity-linked gene SIRT3 mitigates age-related lung fibrosis in mice

Research shows that reducing specific dietary amino acids may hold potential as a translatable intervention to promote healthy aging

Dietary protein restrictions specifically eliminating branch-chain amino acids enhanced male mouse longevity and improved metabolism in both sexes.

Kat7 gene inactivation rejuvenates prematurely aging human cells and mice and promotes longevity.

CRISPR-induced KAT7 gene inactivation rejuvenates prematurely aging human cells and mice and promotes longevity.

Changes in the body that come from space travel resemble growing older, providing opportunities to perform aging studies on astronauts.

Spending time in outer space can mimic the effects of aging, and scientists have begun using the unique environment of space as a place to study aging.

How Aging is Affected by Space Travel

Others

Limited rapamycin exposure late in life was as effective as continuous exposure in increasing survival in males but not females

Late-life rapamycin administration regimens enhance mouse lifespan in a sex-dependent manner with limited exposure more effective in males than females.

A study from UPenn scientists shows rapamycin prevents age-related alterations of metabolic state in muscle cells, which may extend lifespan.

Rapamycin increases the NAD+/NADH ratio and subsequent metabolic balance by reducing NADH levels in mouse muscle.

Genetically modified mouse cells with artificial activation of a nicotinamide adenine dinucleotide (NAD+) regulating enzyme are protected from cessation of cell proliferation induced by stress, maintaining healthy aging.

Artificially-activated Nampt enzyme promotes cellular protection from stress-induced cessation of cell proliferation.

Enzyme Regulating NAD+ Facilitates Cell Replication 

A new study in Mechanisms of Ageing and Development on March 9, 2020, describes how aging fits the criteria for a disease under the International Classification of Disease.

Scientists repurposed a blood cancer treatment using genetically modified immune cells called CAR T cells to reverse age-associated tissue damage.

A cellular therapy typically used against blood cancer called CAR T therapy improved tissue health by destroying senescent cells in mice.

Boosting nicotinamide adenine dinucleotide (NAD+) levels restores improves circadian rhythms in old mice through youthful gene activation and metabolic patterns, revealing that NAD+ governs both behavior and metabolic health.

How NAD+ Counters Aging in the Bodies of Mice

The helminth parasitic worm secretion ES-62 substantially extends male mouse lifespan but not female by promoting gut health 

The parasitic worm helminth secretion factor ES-62 extends male mouse lifespan but not female by improving gut health.

Much of the attention given to restoration of NAD+ levels examine its role in activating sirtuins. Scientific research, though, demonstrates NAD+ supplementation not only has beneficial effects on aging through sirtuin activity but also a variety of age-related disorders

NAD+ supplementation not only has beneficial effects on aging through sirtuin activity but also age-related disorders through improvement of ATP levels.

Studies

NEWS