Nicotinamide mononucleotide (NMN) supplementation improves oocyte quality from naturally aged mice by restoring nicotinamide adenine dinucleotide (NAD+) levels.
As a woman ages, so does her eggs. The decline in the quality and quantity of eggs results in a drop in fertility, but raising the NAD+ level may be a novel way to improve the effects of aging on the egg.
Scientists recently reported that obesity itself or having an obese mother adversely affects sperm quality in mice and that nicotinamide mononucleotide (NMN) supplementation can negatively impact sperm quality, depending on dose.
Scientists from UNSW Sydney and the University of Queensland in Australia, along with David A. Sinclair from Harvard, demonstrate elevation of nicotinamide adenine dinucleotide (NAD+) levels may provide an effective and non-invasive strategy to restore and maintain female fertility during aging. The scientists use the NAD+ precursor, NMN.