Study shows that nicotinamide mononucleotide restores the fertilization ability of oocytes exposed to environmental pollutants

Nicotinamide Mononucleotide protects pig egg cells (oocytes) from ethylene glycol butyl ether, a common chemical found in industrial and household products.

Reproduction

Nicotinamide mononucleotide (NMN) supplementation improves oocyte quality from naturally aged mice by restoring nicotinamide adenine dinucleotide (NAD+) levels.

How NMN Affects Egg Cells and Fertility

Age-associated mitochondrial DNA point mutations reduce oocyte quality in humans, providing a potential biomarker for embryo viability in assisted reproduction

Mitochondrial DNA point mutations acquired during aging reduce oocyte quality in humans and may provide a biomarker for embryo viability in assisted reporduction.

Scientists from UNSW Sydney and the University of Queensland in Australia, along with David A. Sinclair from Harvard, demonstrate elevation of nicotinamide adenine dinucleotide (NAD+) levels may provide an effective and non-invasive strategy to restore and maintain female fertility during aging.  The scientists use the NAD+ precursor, NMN.

Scientists demonstrate the elevation of NAD+ levels may provide an effective and non-invasive strategy to restore and maintain female fertility during aging. 

How NMN Affects Female Fertility in Aging Mice

Scientists recently reported that obesity itself or having an obese mother adversely affects sperm quality in mice and that nicotinamide mononucleotide (NMN) supplementation can negatively impact sperm quality, depending on dose.

How Obesity Affects Sperm Quality in Mice

As a woman ages, so does her eggs. The decline in the quality and quantity of eggs results in a drop in fertility, but raising the NAD+ level may be a novel way to improve the effects of aging on the egg.

Studies

NEWS

NMN Protects Egg Cells from Reproductive Toxins