Studies - Metabolism




Immune Cells Expressing CD38 Drive NAD+ Decline with Age

A new study indicates age-related inflammation can stimulate CD38 positive immune cell consumption of NAD+.


Enzymes on Surfaces of Immune Cells Deplete NMN and NAD+ During Aging

Researchers show that an enzyme called CD38 on immune cells exhausts levels of an essential molecule for life called NAD+ and its precursor NMN during aging.


Neuroscientists Revive Memory Deficits and Brain Cell Loss in Diabetic Rats

Nicotinamide mononucleotide (NMN) intervention protects neurons and memory from diabetes-induced brain degeneration in rats.


Scientists Identify a Mitochondrial NAD+ Transporter

UPenn researchers identify an elusive mechanism for the entry of NAD+ into the power plant of the cell.


A Therapeutic Approach to Falling NAD+ Levels After Brain Injury

Scientists elaborate how NAD+ depletion compromises the ability of mitochondria to counteract free radical and reactive oxygen species buildup.


Binge Drinking Causes Liver Damage by Reducing Cellular Levels of NAD+

Excessive alcohol consumption and binge drinking reduce levels of free nicotinamide adenine dinucleotide (NAD+) critical to cellular health and energy production, resulting in liver and organ damage.


Aging Might Be Reversible — Fixing the Miscommunications in Cells with NAD+

Miscommunication between mitochondria and the nucleus accelerates aging, but NAD+ supplementation helps restore the conversation and reverses signs of aging.