Elimination of growth-arrested cells by inhibiting a metabolic pathway improves age-related tissue dysfunction

Inhibiting the metabolism of the protein building block glutamine improves age-related tissue dysfunction by eliminating growth-arrested cells.

NMN and metformin bound to microscopic nanocrystals called silver quantum dots enhance metabolic function using substantially lower doses in mice.

Silver nanocrystals called quantum dots bound to nicotinamide mononucleotide (NMN) and metformin improve metabolic function at substantially reduced doses in mice reflecting enhanced potency.

One week of nicotinamide riboside (NR) supplementation did not affect whole-body metabolic adaptation before, during, or after working out

Pre-workout nicotinamide riboside (NR) supplementation has no effect on whole-body metabolic adaptation before, during, or after exercise.

Can Pre-Workout NR Influence Exercise? | NMN

Research shows that reducing specific dietary amino acids may hold potential as a translatable intervention to promote healthy aging

Dietary protein restrictions specifically eliminating branch-chain amino acids enhanced male mouse longevity and improved metabolism in both sexes.

Longevity

How does The Sirtfood Diet help you live a healthier and longer life?

The Sirtfood Diet has helped celebrities like Adele lose weight and maintain their physical fitness.

How Adele Lost Weight Using Science

Metabolism

Japanese researchers uncover a new role for NAD+ and α-Ketoglutarate in the development of fat

NMN may be a novel therapeutic option to combat obesity as scientists uncover a new role for NAD+ in the development of fat.

Researchers show that an enzyme called p38gamma that prevents toxicity associated with memory loss.
CD38 on immune cells exhausts levels of an essential molecule for life called NAD+ and its precursor NMN during aging.

CD38 enzymes on the surfaces of immune cells increase with age leading to reduced NAD+ and NMN levels.

Enzymes of Immune Cells Deplete NAD+ During Aging | NMN

Immunity

A study from UPenn scientists shows rapamycin prevents age-related alterations of metabolic state in muscle cells, which may extend lifespan.

Rapamycin increases the NAD+/NADH ratio and subsequent metabolic balance by reducing NADH levels in mouse muscle.

UPenn researchers identify an elusive mechanism for the entry of NAD+ into the power plant of the cell.

Scientists from UPenn identify a transporter that facilitates entry of NAD+ into mammalian mitochondria.

Scientists Identify a Mitochondrial NAD+ Transporter | NMN

Scientists elaborate how NAD+ depletion compromises the ability of mitochondria to counteract free radical and reactive oxygen species buildup.

Decreasing NAD+ Levels After Brain Injury

Hypoglycemia, severely low blood sugar, a common compilation in diabetic patients, can lead to brain injuries. But, NMN may ameliorate neuronal damage and cognitive impairment that follows the condition.

Neurological

Blocking enzymes that deplete NAD+ may treat human metabolic diseases like diabetic kidney disease

Apigenin ameliorates kidney disease in diabetic rats by inhibiting NAD+-consuming enzyme CD38 activity and restoring SIRT3 enzyme function.

The 24-hr internal clock that keeps our us functioning on schedule ticks out of pace as we grow older. Scientists say raising the level of NAD+ can help counter the effects of aging.

Reversing Our Biological Clock May Be Possible via Boosting NAD+

Nicotinamide mononucleotide (NMN) intervention protects neurons and memory from diabetes-induced brain degeneration in rats.

NMN protects brain regions and memory capabilities in brain degeneration from diabetes in rats.

Neuroscientists Revive Memory Deficits and Brain Cell Loss | NMN

Research indicates nicotinamide mononucleotide (NMN) supplementation may prevent cognitive impairment in diabetes patients.

NMN injections preserve neurons and cognitive abilities in rats after severe hypoglycemia, which may translate to helping diabetes patients.

Studies

NEWS

Silver Quantum Dots Enhance Liver Absorption and Therapeutic Effectiveness of NMN and Metformin

Supplementing NAD+ Preserves Neurons and Memory Formation in Rats with Hypoglycemia