Investigators propose that a newly revealed nicotinamide adenine dinucleotide (NAD+) binding site of Sarm1 may be a promising drug target.
Scientists elaborate how NAD+ depletion compromises the ability of mitochondria to counteract free radical and reactive oxygen species buildup.
Nicotinamide adenine dinucleotide (NAD+) regeneration salvages lifespan but not movement and balance problems in mice with brain mitochondrial dysfunction.
Researchers from the University of Maryland and the Veterans Affairs Maryland Health Center recently found that NMN improves mitochondrial NAD+ metabolism and mitochondrial health via SIRT3 in ischemic mice.
Scientists hope that neuroprotective chemicals called P7C3 will become new interventions for nerve cell dysfunction that currently lack treatment options
Scientists provide evidence elucidating the cellular pathway by which calorie restriction reduces plaque buildup in Alzheimer’s disease.
Scientists find NMN improves depression-like behavior, displayed as immobility in swim tests, and cellular energy production in mice.