Studies - Neurological




NAD+ Binds to and Inhibits a Protein that Promotes Degeneration of Neurons

Investigators propose that a newly revealed nicotinamide adenine dinucleotide (NAD+) binding site of Sarm1 may be a promising drug target.


A Therapeutic Approach to Falling NAD+ Levels After Brain Injury

Scientists elaborate how NAD+ depletion compromises the ability of mitochondria to counteract free radical and reactive oxygen species buildup.


Rescuing Lifespan of Leigh Syndrome Mice with NAD+ Regeneration

Nicotinamide adenine dinucleotide (NAD+) regeneration salvages lifespan but not movement and balance problems in mice with brain mitochondrial dysfunction.


Boosting NAD+ Improves Mitochondrial Health Following Cerebral Ischemia

Researchers from the University of Maryland and the Veterans Affairs Maryland Health Center recently found that NMN improves mitochondrial NAD+ metabolism and mitochondrial health via SIRT3 in ischemic mice.


Neuroprotective Chemicals Prevent Neurodegeneration and Preserve Function After Traumatic Brain Injury

Scientists hope that neuroprotective chemicals called P7C3 will become new interventions for nerve cell dysfunction that currently lack treatment options


Eating Less Reduces Plaque Buildup in Alzheimer’s Disease

Scientists provide evidence elucidating the cellular pathway by which calorie restriction reduces plaque buildup in Alzheimer’s disease.


NMN Improves Depression Symptoms in Mice

Scientists find NMN improves depression-like behavior, displayed as immobility in swim tests, and cellular energy production in mice.