The collaboration sets a precedent in longevity drug discovery and development.
Urolithin A bolstered cellular energy production, NAD+ levels, and blood vessel formation in aged muscles of mice.
The NAD+-consuming enzyme SARM1 is a therapeutic candidate for retinal diseases and vision loss.
An orally available NAD+ precursor NR relieves acute kidney injury but not chronic kidney disease.
Researchers discuss data challenging the proposal that NR supplementation improves the function of the cell’s powerhouse, the mitochondria, in humans.
Potential therapeutic modulations of Sirtuins through synthetic- and plant-derived compounds can help design new-generation cheap, non-toxic Sirtuin-based drugs against lung fibrosis.
Scientists at Nanchang University discovered NMN may be a therapeutic option for glucocorticoid-induced osteoporosis.